Cervical cancer screening, including Pap smears and human papillomavirus (HPV) testing, should be discontinued in this patient. Screening for cervical cancer can be stopped in women age 65 years and older who have had adequate prior screening, which consists of three consecutive negative Pap smears or two consecutive negative Pap smears plus HPV tests within the last 10 years. The most recent testing should be within the last 5 years. This patient meets these criteria with consistently negative Pap smear screenings, with the latest being 2 years ago. The American Cancer Society recommends that screening not continue in women over age 65 years, even in those who have a new sexual partner. Women who have had a hysterectomy with removal of the cervix for benign reasons (no history of high-grade precancerous lesions or cervical cancer) should not be screened regardless of age. This includes women who have had a hysterectomy with removal of the cervix during surgery for ovarian or endometrial cancer, as they are not considered to be at high risk for cervical cancer.

In women age 65 years and older who are at high risk for cervical cancer, including immunocompromised women (such as those with HIV infection), women with in utero exposure to diethylstilbestrol (DES), and women who have had previous treatment of a high-grade precancerous lesion, screening should continue.